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Last year researchers identified a new gene mutation associated with
the disorder. Known mutations have only explained a small number of
Tourette’s cases, so the investigators, led by Matthew State,
co-director of the Yale Neurogenetics Program, studied a rare family in
which the father and his eight children all had Tourette’s. In these
family members, the gene involved in the production of histamine in the
brain was shorter than normal, generating lower levels of the compound,
which is involved in inflammatory response. State believes these lower
levels can cause tics, and he is looking for this and further
histamine-related mutations in other people with Tourette’s.
Now scientists have found parallels between this family and
histamine-deficient mice, which furthers the connection to Tourette’s.
Most individuals with Tourette’s have low prepulse inhibition, meaning
that they are more easily startled or distracted than the average
person, says Christopher Pittenger, director of the Yale OCD Research
Clinic. In May he was to present new data to the Society of Biological
Psychiatry that both this family and mice missing the histamine gene had
low prepulse inhibition and tics. Other experiments have shown that
histamine-boosting drugs decrease ticlike behaviors in mice.
In a recently screened BBC documentary, UK
neuroscientists suggested that the brains of Apple devotees are
stimulated by Apple imagery in the same way that the brains of religious
people are stimulated by religious imagery.
People have
often talked about “the cult of Apple”, and if a recent BBC TV
documentary is to be believed, there could be something in it.
The program, Secrets of the Superbrands,
looks at why technology megabrands such as Apple, Facebook and Twitter
have become so popular and such a big part of many people’s lives.
In
the first episode, presenter Alex Riley decided to take a look at
Apple. He wanted to discover what it is about the company that makes
people so emotional. Footage of the opening of the Cupertino company’s
Covent Garden store in central London last year showed hordes of Apple
devotees lining up outside overnight, while the staff whipped up
customers (and themselves) into something of an evangelical frenzy. This
religious-like fervour got Riley thinking – he decided to take a closer
look at the inside of the head of an Apple fanatic to see what on earth
was going on in there.
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The motor outputs of children with Tourettes syndrome are under
greater cognitive control. You might view this as their being less
likely to respond without thinking, or as being less reflexive.
This helps explain why some people may have many tics as children,
but as adults have very few. Over time, their brains have developed ways
to control these tics. Jackson points out that this may mean people
with Tourettes need mental exercises rather than brain surgery or drugs,
because their brains will naturally develop compensatory mechanisms.
The preliminary study picks up where investigators left off. It
explores the possible therapeutic effects of the drug on the intense
anxiety experienced by patients with life-threatening disease, such as cancer.
A number of the hundreds of studies conducted on lysergic acid
diethylamide-25 from the 1940s into the 1970s (many of poor quality by
contemporary standards) delved into the personal insights the drug
supplied that enabled patients to reconcile themselves with their own
mortality. In recent years some researchers have studied psilocybin (the
active ingredient in “magic mushrooms”) and MDMA (Ecstasy), among
others, as possible treatments for this “existential anxiety,” but not
LSD.
Gasser, head of the Swiss Medical Society for Psycholytic Therapy,
which he joined after his own therapist-administered LSD experience, has
only recently begun to discuss his research, revealing the challenges
of studying psychedelics. The $190,000 study approved by Swiss medical
authorities, was almost entirely funded by the Multidisciplinary
Association for Psychedelic Studies, a U.S. nonprofit that sponsors
research toward the goal of making psychedelics and marijuana into
prescription drugs. Begun in 2008, the study intends to treat 12
patients (eight who will receive LSD and four a placebo). Finding
eligible candidates has been difficult—after 18 months only five
patients had been recruited, and just four had gone through the trial’s
regimen of a pair of all-day sessions. “Because LSD is not a usual
treatment, an oncologist will not recommend it to a patient,” Gasser
laments.
The patients who received the drug found the experience aided them
emotionally, and none experienced panic reactions or other untoward
events. One patient, Udo Schulz, told the German weekly Der Spiegel
that the therapy with LSD helped him overcome anxious feelings after
being diagnosed with stomach cancer, and the experience with the drug
aided his reentry into the workplace.
The trials follow a strict protocol—“all LSD treatment sessions will
begin at 11 a.m.”—and the researchers are scrupulous about avoiding
mistakes that, at times, occurred during older psychedelic trials, when
investigators would leave subjects alone during a drug session. Both
Gasser and a female co-therapist are present throughout the eight-hour
sessions that take place in quiet, darkened rooms, with emergency
medical equipment close at hand. Before receiving LSD, subjects have to
undergo psychological testing and preliminary psychotherapy sessions.
Another group is also pursuing LSD research. The British-based
Beckley Foundation is funding and collaborating on a 12-person pilot
study at the University of California, Berkeley, that is assessing how
the drug may foster creativity and what changes in neural activity go
along with altered conscious experience induced by the chemical. Whether
LSD will one day become the drug of choice for psychedelic
psychotherapy remains in question because there may be better solutions.
“We chose psilocybin over LSD because it is gentler and generally less
intense,” says Charles S. Grob, a professor of psychiatry at the
University of California, Los Angeles, who conducted a trial to test
psilocybin’s effects on anxiety in terminal cancer patients. Moreover,
“it is associated with fewer panic reactions and less chance of paranoia
and, most important, over the past half a century psilocybin has
attracted far less negative publicity and carries far less cultural
baggage than LSD.”
Scientists have found that people with conservative views have brains with
larger amygdalas, almond shaped areas in the centre of the brain often
associated with anxiety and emotions.
On the other hand, they have a smaller anterior cingulate, an area at the front
of the brain associated with courage and looking on the bright side of life.